Aktivitas Antioksidan pada Minuman Fungsional Berbasis Jahe dan Kacang-Kacangan sebagai Antiemetik

Leny Budhi Harti, Fuadiyah Nila Kurniasari, Kusumaningrum Dasilva, Elok Waziiroh, Anggun Rindang Cempaka

Abstract


Antioksidan merupakan salah satu zat gizi yang dapat menurunkan mual dan muntah. Antioksidan ini dapat ditemukan pada bahan makanan seperti jahe, kacang kedelai, dan kacang hijau. Bahan makanan tersebut dapat dikonsumsi dalam bentuk minuman fungsional. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan pada minuman fungsional berbasis jahe dan kacang-kacangan yang dapat membantu mengatasi mual dan muntah. Desain dari penelitian ini adalah eksploratif deskriptif. Sampel pada penelitian ini yaitu 16 formula yang didapatkan dengan metode d-optimal Mixture Design pada software Design Expert 7®. Software design expert ini mampu menentukan proporsi sari jahe, sari kacang hijau, dan sari kacang kedelai. Aktivitas antiosidan diukur menggunakan metode DPPH yang disajikan dalam bentuk nilai aktivitas antioksidan IC50. IC50 didefinisikan sebagai konsentrasi antioksidan yang dapat menangkap 50% radikal bebas DPPH. Hasil penelitian ini menunjukkan bahwa nilai aktivitas antioksidan IC50 formula 1 hingga 16 adalah 109,20; 104,08; 102,66; 147,88; 99,42; 129,89; 132,53; 115,87; 136,94; 109,78; 139,78; 99,33; 102,26; 135,46; 116,07; 120,45 mg/ml. Semakin kecil nilai IC50 menunjukkan bahwa aktivitas antioksidannya semakin baik. Terdapat perbedaan aktivititas antioksidan yang signifikan dari 16 formula (p = 0,0048).  Kesimpulan dari penelitian ini yaitu terdapat aktivitas antioksdan pada formula minuman fungsional berbahan dasar jahe dan kacang-kacangan sebesar 99,33 mg/ml hingga147,88 mg/ml.   

Kata kunci: aktivitas antioksidan, mual, muntah,  minuman fungsional

Abstract
Antioxidant is one of the nutrients that can reduce nausea and vomiting. It can be found in ginger, soy bean, and green beand. They can be consumed as functional drinks. This study aimed to determine the antioxidant activity on functional drinks based on ginger and beans that can reduce nausea and vomiting. Sample in this study is 16 formula which got by d-optimal Mixture Design method in software Design Expert 7®. That design was used to decide the proportion of ginger extract, green bean extract, and soybean extract. Antioxidant activity was measured by DPPH. It was dercribed by IC50 score of antioxidant activity. Result of this research showed that IC50 Score of antioxdant activity formula 1-16 were 109.20; 104.08; 102.66; 147.88; 99.42; 129.89; 132.53; 115.87; 136.94; 109.78; 139.78; 99.33; 102.26; 135.46; 116.07; 120.45 mg/ml respectively. The smaller score of IC50 indicated that antioxidant activity was better than the higher score.  Statistical analysis indicated a significant different (p < 0,005) on antioxidant activity among formulas (p = 0,0048). From this study could be concluded there were antioxidant activity in ginger formula about 99.33 mg/ml until 147.88 mg/ml.

Keywords: antioxidant activity, nausea, vomiting, functional drink


Keywords


aktivitas antioksidan, mual, muntah, minuman fungsional

Full Text:

PDF

References


Lee NM, Saha S. Nausea and Vomiting of Pregnancy. Gastroenterol Clin North Am. 2011; 40 (2): 309–vii.

Harijanto E. Penatalaksanaan Mual-Muntah Pascabedah (PONV): Peran Granisetron. Medicinus. 2011; 23 (3): 13-15.

Fithrah BA. Penatalaksanaan Mual Muntah Pascabedah di Layanan Kesehatan Primer. CDK-217. 2014; 41 (6): 407–411.

McDonagh M, Peterson K, Thakurta S. Consideration of Evidence on Antiemetic Drugs for Nausea and Vomitting Associated with Chemotherapy or Radiation Theraphy in Adults. Oregon: Department of Health Human Service USA; 2010.

Kumar S, Saxena K, Singh UN, Saxena R. Anti-inflammatory Action of Ginger: A Critical Review in Anemia of Inflammation and Its Future Aspect. International Journal of Herbal Medicine. 2011; 1 (4): 16-20.

Pratap SR., Ritesh J, Rahul M, Prashant T. Antidepressant Activity of Hydroalcoholic Extract of Zingiber officinale. International Research Journal of Pharmacy. 2012; 3 (2): 149-151.

Nurhalimah L, Fathonah S, & Nurani, D. Kandungan Gizi Dan Daya Terima Makanan Tambahan Ibu Hamil Trimester Pertama. Food Science And Culinary Education Journal , 2012,19-25.

Wiraharja, R.S., Rustam, S. & Iskandar, M.Kegunaan Jahe Untuk Mengatasi Gejala Mual Dalam Kehamilan , 2011, 10(3):161–170.

Masrurah, S. & Wulan, A.J. Khasiat Jahe ( Zingiber officinale ) Sebagai Anti Mual dan Muntah pada Wanita Hamil Efficacy of Ginger ( Zingiber officinale ) As An Anti Nausea and Vomiting in Pregnant Women. , 2016, 5: 107–111.

Mošovskáa, S., Novákováa, D., & Kaliňákb, M. Antioxidant Activity Of Ginger Extract And Identification Of Its Active Components. Acta Chimica Slovaca ,2011, 8 (2): 115—119.

Ghasemzadeh, A. & Ghasemzadeh, N. Flavonoids and phenolic Acids: Role And Biochemical Activity In Plants And Human. Journal of Medicinal Plants Research, 2011, 5(31): 6697–6703.

Fatma, Celik., Irfan, Guzel. A., Umur, Kuyumcuoglu & Yusuf, Celik. Dietary Antioxidant Levels In Hyperemesis Gravidarum: A Case Control Study. Ginekologia polska, 2011, 82(11): 840–844.

Alam J., Subhan F., Ullah I., Shahid M., Ali G., Sewel RDE. Synthetic and Natural Antioxidants Attenuate Cisplatin-Induced Vomiting. BMC Pharmacology and Toxicology 2017;18(4):1-6

Molyneux, P. The Use Of The Stable Free Radical Diphenylpicryl-Hydrazil (DPPH) For Estimating Antioxidant Activity. Songklanakarin Journal Science Tecnology, 2004, 26,211-219.

Salem, S. A, El-Mergawi, R. A. & I. S. Ashoush. Effect Of Technological Processing And Fermentation Of Soy Milk on The Content of Isoflavones and Antioxidant Status. IMPACT: International Journal of Research in Applied, Natural and Social Sciences (IMPACT: IJRANSS),2015, 3(5): 1-8.

Chakraborty, Arijita & Bhatta-charyya, Sauryya. Thermal processing effects on in vitro Antioxidant activities of five common Indian Pulses. Journal of Applied Pharmaceutical Science, 2014, 4(05): 65-70.




DOI: http://dx.doi.org/10.21776/ub.ijhn.2018.005.01.2

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.